Through translational research and dissemination of knowledge, it is our hope that the Centre for Physical Activity Research (CFAS) will be able to develop targeted exercise training regimes for specific disease groups by applying an unconventional strategy that we label: “from man to molecule and back”.
A key principle of the centre is that the research carried out in the laboratories can find direct application in the real world. Thus, training regimes that demonstrate promising results in a laboratory setting will be further tested and developed in large patient groups in a model municipality and/or at a model hospital department before the optimal training mode is translated into relevant national health institutions.
It is our wish that new research discoveries will be implemented and anchored in society, leading to change of praxis.
Solid epidemiological data shows that exercise training can reduce disease risk and mortality for several cancer diagnoses, and in addition to improving the functional capacity of cancer patients, exercise training may directly regulate tumor physiology and metabolism. Exercise training has the potential to be a beneficial and integrated component of cancer management, yet to fully elucidate its potential, understanding of the mechanistic effects of exercise on tumor physiology is warranted. We focus on gaining such insight into the mechanistic effects of exercise on tumor biology and physiology through a translational approach with cell culture studies, animal models and exercise interventions in cancer patients.
Physical activity is a cornerstone in self-management behaviour for patients with chronic illness. However, several studies have found that it is a challenge for patients with chronic illness to maintain lifestyle changes such as physical activity over time. Therefore, it is highly relevant to obtain more knowledge on how we can organize suitable rehabilitation programmes in a way that continues to motivate patients with chronic illness towards lasting lifestyle changes.
Few days of bed rest has pronounced negative effects on fitness and metabolism, and just 14 days of sedentary lifestyle has substantial effects on fitness, glucose metabolism and body composition.
Type 2 diabetes is a complex disease and obesity represents a strong risk factor for disease progression. Several tissues are deregulated and become dysfunctional including the main units for energy disposal and storage: skeletal muscle and fat tissue. Balancing the level of muscle usage with the amounts of lipids stored in the fat cells is crucial for metabolic homeostasis and is regulated at several levels.